Royal Air Force Typhoon fighter aircraft have operated alongside France's air force in a joint strike on an underground arms cache in Syria used by the IS group, according to the UK Ministry of Defence.
The location, pinpointed through intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was located in mountainous terrain just above the ancient city of Palmyra in central Syria.
"The RAF jets utilized laser-guided Paveway IV weapons to hit a several entry passages down to the depot... preliminary assessments are that the target was engaged successfully," the MoD said.
There was no evidence of any harm to civilians in the attack conducted Saturday night and each participating jet made a safe return, the defence officials confirmed.
The British jets were assisted by a Voyager refuelling tanker.
IS - also known as the so-called Islamic State - imposed extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This strike shows British leadership, and commitment to stand shoulder to shoulder with allied nations, to eradicate any re-emergence of IS and their violent and radical beliefs in the area," Britain's Defence Chief John Healey stated.
UK warplanes have performed patrols over Syrian airspace to "forestall any efforts to regroup" of the group after its routing at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I extend gratitude to all the members of the UK armed forces who took part in this strike for their skill and their bravery," he said. "They were part of numerous British personnel deployed over the holidays. This operation, to remove militants who pose a risk to our safety, shows how our armed forces are ready to step up, all year round, protecting the UK at home and influential overseas."
In December, the American forces carried out what it called a "massive strike" on Daesh sites in the country, subsequent to an ambush killed two American soldiers and a local interpreter in Palmyra.
The U.N. estimates Daesh still maintains roughly 5-7 thousand fighters in Syria and Iraq.